Should I Fill All Ram Slots

First, I apologize if this has been covered elsewhere; I searched the forums and didn't find this particular question.
This is my first build, so I have the following background info for my question (at the bottom):
I have 3x4GB sticks of RAM (CMZ4GX3M1A1600C9) from my previous triple-channel mobo. The Maximus Vii hero user guide
indicates that the RAM I have is compatible with the board. The guide says that the 'DIMM Socket Support (Optional)' supports '2',
but not '4'. Which refers to the following:
'(2) Supports two (2) modules inserted into either the red slots or the black slots as one pair of Dual-Channel memory
configuration.'
Question: This might be a newb question, but can I use all three sticks? Configure two of the DIMMs for Dual-Channel, and then
simply add the last stick in the appropriate open slot? Doing so won't cause the Maximus not to POST or somehow damage the
board?
Thanks folks.

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Yea, I'm running 4gigs with 4 slots filled on one computer and 2 slots filled on another, and I don't really see any difference at all. So I'm going to have to say it doesn't matter too much in the way of speed, so it is probably better to get 2 sticks so you can upgrade later if you need to. Why upgrade your RAM Many PC owners won't necessarily need to ever update their RAM. But if one day you decide to, you might understandably make the assumption that adding faster and larger amounts. No, they do not all have to be the same although many here have found that the should be the same in side-by-side slots. I am currently running the configuration below. Many on this forum, as do I, also recommend that you use only Crucialor OWCRAM chips as bargain brand RAM often will not work.